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Central portion of frontalis muscle less mobile than more lateral portions
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Hansen disease
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  • The forehead and face become smooth and unlined in fascioscapulohumeral dystrophy (Landouzy-Déjérine). [101]
  • Card EA-010 mentions that gouty tophi form in the earlobes. [102]
  • The solubility of uric acid at pH 7.4 and 37°C is 6.8 mg/dL, versus 4.5 mg/dL at 30°C. Thus, it is possible to have gout (precipitation of urate crystals) without hyperuricemia if the temperature, and other conditions, are right. This article presents such a case. [103]
  • Mentions that livedo reticularis is usually most evident on the lower limbs, where cooler temperatures increase the blood viscosity. [104]
    Footnotes in Print Edition[Top] [Nav]
    (1) Peripheral Neuropathy.
  Dyck PJ (ed). Philadelphia: Saunders, 1975: 1180-1181.
    (2) Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1979.
  N Engl J Med 1979 Mar 8;300(10):546-53.  Pubmed  Similars
    (3) Management of Headache. 3rd ed.
  Lance JW. London-Boston: Butterworths, 1978: 8.
    (4) DeGowin & DeGowin's Bedside Diagnostic Examination. 5th ed.
  DeGowin RL. NY: Macmillian, 1987: 82.   Amazon.com
    (5) The influence of temperature on the solubility of monosodium urate.
  Loeb JN.   Arthritis Rheum 1972 Mar-Apr;15(2):189-92.  Pubmed  Similars
    New References[Top] [Nav]

Head and face
    101.Heart Disease. 3rd ed.
  Braunwald E, et al. Philadelphia: Saunders, 1988: 1786.   Amazon.com
    102.Card EA-010 mentions that gouty tophi form in the earlobes.

Low-temperature effects in the extremities
    103.Gout without hyperuricemia.
  McCarty DJ.   JAMA 1994 Jan 26;271(4):302-3.  Pubmed  Similars
    104.Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 30-1995. A 69-year-old woman with lupus erythematosus and painful skin lesions of the feet [clinical conference].
  N Engl J Med 1995 Sep 28;333(13):862-8.  Pubmed  Similars
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    ©1986-2000 John Sotos, MD. All rights reserved.  Last updated 16:34 PDT on July 4, 2000.[Top]

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