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Heroin that causes a burning sensation at the site of injection
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"synthetic heroin" containing MPTP
    Discussion -- not available online[Top] [Nav]
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  • The story of MPTP and parkinsonism, by the physician who identified the clinical syndrome and the toxin. Notes that MPTP had been available for many years from Aldrich Chemical Company, selling for $11 in 1982. However, after the hullaballoo about MPTP in parkinsonism began, Aldrich raised the proce to $9500! [102]
  • MPTP is a byproduct of meperidine synthesis. This letter reports a case of reversible parkinsonism resulting from administration of meperidine to control post-operative pain. The authors postulate that the meperidine was somehow metabolized to an MPTP-like substance. No doubt there has been more written about such patients. [103]
    Footnotes in Print Edition[Top] [Nav]
    (1) Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP): seven cases.
  Ballard PA, Tetrud JW, et al.   Neurology 1985 Jul;35(7):949-56.  Pubmed+Abstract  Similars
    (2) A growing industry and menace: makeshift laboratory's designer drugs [news].
  Ziporyn T.   JAMA 1986 Dec 12;256(22):3061-3.  Pubmed  Similars
    (3) The Impact of Illness on World Leaders.
  Park BE. Philadelphia: University of Pennsylvania Press, 1986: 187-188.   Amazon.com
    New References[Top] [Nav]
MPTP-induced parkinsonism
    101.The clinical syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
  Burns RS, LeWitt PA, et al.   N Engl J Med 1985 May 30;312(22):1418-21.  Pubmed+Abstract  Similars
    102.The Case of the Frozen Addicts.
  Langston JW, Palfreman J. New York: Pantheon, 1995: 309 pp.   Amazon.com
Other causes of parkinsonism
    103.Reversible parkinsonism related to meperidine [letter].
  Lieberman AN, Goldstein M.   N Engl J Med 1985 Feb 21;312(8):509.  Pubmed  Similars
    104.Cyanide-induced parkinsonism: a clinicopathologic report.
  Uitti RJ, Rajput AH, et al.   Neurology 1985 Jun;35(6):921-5.  Pubmed+Abstract  Similars
    105.Diagnosis of chronic manganese intoxication by magnetic resonance imaging [letter].
  Arjona A, Mata M, et al.   N Engl J Med 1997 Mar 27;336(13):964-5.  Pubmed  Similars
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    ©1986-2000 John Sotos, MD. All rights reserved.  Last updated 16:34 PDT on July 4, 2000.[Top]

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