Zebra Cards > Update > Blood > BL-001  
 

    BL-001Prior: AB·008 « Nav » Next: BL·002
Bleeding one week after a blood transfusion
    Differential Diagnosis[Top] [Nav]
post-transfusion purpura due to anti-platelet antibodies
    Discussion -- not available online[Top] [Nav]
    Update Comments[Top] [Nav]
  • Identifies PLA2 antigen as a major risk factor for coronary disease [104]
  • Concludes that PLA2 antigen is not a cardiovascular risk. [105]
  • Editorial on Ridker and Weiss papers. [106]
  • PLA2 antigen increases risk of coronary stent thrombosis. [108]
  • PLA1/PLA1 and PLA1/PLA2 have the same tendency to aggregate in the absence of aspirin. In the presence of aspirin, however, PLA1/PLA2 have a ten-fold reduction in their aggregation tendency compared to the effect on PLA1/PLA1 platelets. [109]
  • Two-time Olympic gold medal skater Sergei Grinkov died in 1995 of a myocardial infarction at age 28. His only known cardiovascular risk factor was PLA2 antigen. [107]
    Footnotes in Print Edition[Top] [Nav]
    (-) Post-transfusion purpura: a heterogeneous syndrome.
  Zeigler Z, Murphy S, et al.   Blood 1975 Apr;45(4):529-36.  Pubmed+Abstract  Similars
    (-) Immune thrombocytopenias and platelet antibodies.
  Moore SB.   Mayo Clin Proc 1982 Dec;57(12):778-80.  Pubmed  Similars
    (-) Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 8-1988. A 65-year-old woman with endometrial carcinoma and thrombocytopenia of recent origin.
  N Engl J Med 1988 Feb 25;318(8):500-8.  Pubmed  Similars
    New References[Top] [Nav]
    101.Post-transfusion purpura.
  Mueller-Eckhardt C.   Br J Haematol 1986 Nov;64(3):419-24.  Pubmed  Similars
    102.Post-transfusion purpura.
  Waters AH.   Blood Rev 1989 Jun;3(2):83-7.  Pubmed+Abstract  Similars
    103.Post-transfusion purpura: a report of five patients and a review of the pathogenesis and management.
  Vogelsang G, Kickler TS, et al.   Am J Hematol 1986 Mar;21(3):259-67.  Pubmed+Abstract  Similars
PLA2 antigen and cardiovascular risk
    104.A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis [see comments].
  Weiss EJ, Bray PF, et al.   N Engl J Med 1996 Apr 25;334(17):1090-4.  Pubmed+Abstract  Similars
    105.PIA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis [see comments].
  Ridker PM, Hennekens CH, et al.   Lancet 1997 Feb 8;349(9049):385-8.  Pubmed+Abstract  Similars
    106.Platelet alloantigens: cardiovascular as well as immunological risk factors? [comment].
  Newman PJ.   Lancet 1997 Feb 8;349(9049):370-1.  Pubmed  Similars
    107.Flaws of the heart: sudden death in athletes is often caused by cardiac defects.
  Fackelmann K.   Science News. 1996;150:76-77.
    108.Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis [see comments].
  Walter DH, Schachinger V, et al.   Lancet 1997 Oct 25;350(9086):1217-9.  Pubmed+Abstract  Similars
    109.PlA2 polymorphism and efficacy of aspirin [letter].
  Cooke GE, Bray PF, et al.   Lancet 1998 Apr 25;351(9111):1253.  Pubmed  Similars
    Navigation[Top]
    BL:  001  002  003  004  005  006
    AB BL DI EA EN EX EY FA GE GI GU HD HE IM LU MO MU NC NE NO SK TH VI WI
    All systems
    ©1986-2000 John Sotos, MD. All rights reserved.  Last updated 16:35 PDT on July 4, 2000.[Top]

Home  |  Search  |  Site Map  |  Order  |  Update  |  Feedback  |  Top  |  Prior  |  Next